FABP1

FABP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F73, 2L67, 2L68, 2LKK, 2PY1, 3B2H, 3B2I, 3B2J, 3B2K, 3B2L, 3STK, 3STM, 3STN, 3VG2, 3VG3, 3VG4, 3VG5, 3VG6, 3VG7
Identifiers
Aliases	FABP1, FABPL, L-FABP, fatty acid binding protein 1
External IDs	OMIM: 134650; MGI: 95479; HomoloGene: 1106; GeneCards: FABP1; OMA:FABP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	88,128,062 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,182,007 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; jejunal mucosa; ; mucosa of sigmoid colon; ; mucosa of ileum; ; rectum; ; right lobe of liver; ; cecum; ; human kidney; ; appendix; ; duodenum;
	Top expressed in
	left lobe of liver; ; migratory enteric neural crest cell; ; gallbladder; ; duodenum; ; jejunum; ; human fetus; ; yolk sac; ; right lung lobe; ; epithelium of small intestine; ; intestinal villus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	long-chain fatty acid transporter activity; transporter activity; chromatin binding; fatty acid binding; bile acid binding; antioxidant activity; protein binding; phospholipid binding; lipid binding;
Cellular component	nucleoplasm; apical cortex; peroxisomal matrix; extracellular exosome; nucleus; cytoplasm; cytosol; protein-containing complex;
Biological process	positive regulation of fatty acid beta-oxidation; positive regulation of hydrolase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; triglyceride catabolic process; positive regulation of cell population proliferation; intestinal absorption; cellular response to hypoxia; cellular response to hydrogen peroxide; long-chain fatty acid transport; cellular oxidant detoxification; regulation of lipid metabolic process; transport;
	Sources:Amigo / QuickGO
Orthologs
	2168
	14080
	ENSG00000163586
	ENSMUSG00000054422
	P07148
	P12710
	NM_001443
	NM_017399
	NP_001434
	NP_059095
	Wikidata
View/Edit Human	View/Edit Mouse

FABP1 is a human gene coding for the protein product FABP1 (Fatty Acid-Binding Protein 1). It is also frequently known as liver-type fatty acid-binding protein (LFABP).

FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. Altered expression of the protein has been linked to metabolic conditions including obesity.