FAF1

FAF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1H8C, 2DZM, 2EC4, 3E21, 3QC8, 3QCA, 3QQ8, 3QWZ, 3QX1, 3R3M
Identifiers
Aliases	FAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1
External IDs	OMIM: 604460; MGI: 109419; HomoloGene: 5120; GeneCards: FAF1; OMA:FAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	50,960,267 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	109,821,157 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left testis; ; right testis; ; muscle of thigh; ; ganglionic eminence; ; glutes; ; triceps brachii muscle; ; ventricular zone; ; Skeletal muscle tissue of rectus abdominis; ; body of pancreas;
	Top expressed in
	Paneth cell; ; internal carotid artery; ; facial motor nucleus; ; external carotid artery; ; digastric muscle; ; spermatocyte; ; triceps brachii muscle; ; epithelium of lens; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heat shock protein binding; protein domain specific binding; NF-kappaB binding; ubiquitin binding; protein binding; protein kinase regulator activity; protein kinase binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; cytosol; CD95 death-inducing signaling complex; nuclear envelope; VCP-NPL4-UFD1 AAA ATPase complex; perinuclear region of cytoplasm; nucleus;
Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of cell death; positive regulation of protein-containing complex assembly; cytoplasmic sequestering of NF-kappaB; regulation of cell adhesion; regulation of protein catabolic process; positive regulation of apoptotic process; apoptotic process; regulation of protein kinase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; cell death; positive regulation of DNA replication;
	Sources:Amigo / QuickGO
Orthologs
	11124
	14084
	ENSG00000185104
	ENSMUSG00000010517
	Q9UNN5
	P54731
	NM_131917; NM_007051
	NM_007983
	NP_008982
	NP_032009
	Wikidata
View/Edit Human	View/Edit Mouse

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.