FAM162A

FAM162A
Identifiers
Aliases	FAM162A, C3orf28, E2IG5, HGTD-P, family with sequence similarity 162 member A
External IDs	OMIM: 608017; MGI: 1917436; HomoloGene: 8656; GeneCards: FAM162A; OMA:FAM162A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,412,334 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,891,964 bp
RNA expression pattern
	Top expressed in
	mucosa of sigmoid colon; ; vulva; ; right ventricle; ; gums; ; oral cavity; ; myocardium; ; gingival epithelium; ; myocardium of left ventricle; ; mucosa of transverse colon; ; human penis;
	Top expressed in
	endocardial cushion; ; atrioventricular valve; ; esophagus; ; condyle; ; atrium; ; embryo; ; cumulus cell; ; umbilical cord; ; embryo; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane; mitochondrion; cytosol;
Biological process	apoptotic process; neuron apoptotic process; positive regulation of release of cytochrome c from mitochondria; activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	26355
	70186
	ENSG00000114023
	ENSMUSG00000003955
	Q96A26
	Q9D6U8
	NM_014367
	NM_027342
	NP_055182
	NP_081618
	Wikidata
View/Edit Human	View/Edit Mouse

Human growth and transformation-dependent protein (HGTD-P), also called E2-induced gene 5 protein (E2IG5), is a protein that in humans is encoded by the FAM162A gene on chromosome 3. This protein promotes intrinsic apoptosis in response to hypoxia via interactions with hypoxia-inducible factor-1α (HIF-1α). As a result, it has been associated with cerebral ischemia, myocardial infarction, and various cancers.