FAM76A

FAM76A
Identifiers
Aliases	FAM76A, family with sequence similarity 76 member A
External IDs	MGI: 2385211; HomoloGene: 27071; GeneCards: FAM76A; OMA:FAM76A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,763,116 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,649,869 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; gonad; ; sural nerve; ; right testis; ; left testis; ; secondary oocyte; ; right lobe of thyroid gland; ; right uterine tube; ; smooth muscle tissue;
	Top expressed in
	iris; ; sciatic nerve; ; spermatid; ; conjunctival fornix; ; median eminence; ; ciliary body; ; Epithelium of choroid plexus; ; Region I of hippocampus proper; ; ventromedial nucleus; ; decidua;
	More reference expression data
	n/a
Gene ontology
Molecular function	endopeptidase activity; SUMO-specific protease activity;
Cellular component	nucleoplasm;
Biological process	protein desumoylation;
	Sources:Amigo / QuickGO
Orthologs
	199870
	230789
	ENSG00000009780
	ENSMUSG00000028878
	Q8TAV0
	Q922G2
	NM_152660; NM_001143912; NM_001143913; NM_001143914; NM_001143915
	NM_001163792; NM_145553
	NP_001137384; NP_001137385; NP_001137386; NP_001137387; NP_689873
	NP_001157264; NP_663528
	Wikidata
View/Edit Human	View/Edit Mouse

FAM76A is a protein that in Homo sapiens is encoded by the FAM76A gene. Notable structural characteristics of FAM76A include an 83 amino acid coiled coil domain as well as a four amino acid poly-serine compositional bias. FAM76A is conserved in most chordates but it is not found in other deuterostrome phlya such as echinodermata, hemichordata, or xenacoelomorpha—suggesting that FAM76A arose sometime after chordates in the evolutionary lineage. Furthermore, FAM76A is not found in fungi, plants, archaea, or bacteria. FAM76A is predicted to localize to the nucleus and may play a role in regulating transcription.