Fanconi anemia, complementation group C

FANCC
Identifiers
Aliases	FANCC, Fancc, Facc, FA3, FAC, mir-3074-1, FACC, Fanconi anemia complementation group C, FA complementation group C
External IDs	OMIM: 613899; MGI: 95480; HomoloGene: 109; GeneCards: FANCC; OMA:FANCC - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	95,426,796 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	63,645,092 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right lobe of liver; ; testicle; ; gonad; ; right testis; ; left testis; ; sural nerve; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; Achilles tendon;
	Top expressed in
	zygote; ; secondary oocyte; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; ilium; ; plantaris muscle; ; corneal stroma; ; primary oocyte; ; interventricular septum; ; Ileal epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; Fanconi anaemia nuclear complex; nucleus; nucleoplasm;
Biological process	interstrand cross-link repair; DNA repair; cellular response to DNA damage stimulus; myeloid cell homeostasis; nucleotide-excision repair; gamete generation; germ cell development; removal of superoxide radicals; cellular response to oxidative stress; brain morphogenesis; neuronal stem cell population maintenance; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	2176
	14088
	ENSG00000158169
	ENSMUSG00000021461
	Q00597
	P50652
	NM_000136; NM_001243743; NM_001243744
	NM_001042673; NM_001282942; NM_007985; NM_001347514; NM_001347515
	NP_000127; NP_001230672; NP_001230673
	NP_001036138; NP_001269871; NP_001334443; NP_001334444; NP_032011
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi anemia group C protein is a protein that in humans is encoded by the FANCC gene. This protein delays the onset of apoptosis and promotes homologous recombination repair of damaged DNA. Mutations in this gene result in Fanconi anemia, a human rare disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages.