FANCM

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Structures	Swiss-model
Domains	InterPro

Fanconi anemia, complementation group M
Fanconi anemia, complementation group M
Identifiers
Symbol	FANCM
Alt. symbols	KIAA1596
NCBI gene	57697
HGNC	23168
OMIM	609644
PDB	4BXO
RefSeq	XM_048128
UniProt	Q8IYD8
Other data
EC number	3.6.1.-
Locus	Chr. 14 q21.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

FANCM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BXO, 4DAY, 4DRB, 4E45, 4M6W
Identifiers
Aliases	FANCM, FAAP250, KIAA1596, Fanconi anemia complementation group M, FA complementation group M, POF15, SPGF28
External IDs	OMIM: 609644; MGI: 2442306; HomoloGene: 35378; GeneCards: FANCM; OMA:FANCM - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	45,200,890 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	65,178,832 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; testicle; ; secondary oocyte; ; ventricular zone; ; gonad; ; right testis; ; left testis; ; Achilles tendon; ; ganglionic eminence;
	Top expressed in
	tail of embryo; ; blastocyst; ; genital tubercle; ; morula; ; morula; ; zygote; ; secondary oocyte; ; epiblast; ; ventricular zone; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nuclease activity; nucleotide binding; chromatin binding; protein binding; ATP binding; hydrolase activity; helicase activity; 3'-5' DNA helicase activity;
Cellular component	FANCM-MHF complex; Fanconi anaemia nuclear complex; nucleus; nucleoplasm;
Biological process	resolution of meiotic recombination intermediates; interstrand cross-link repair; replication fork processing; nucleic acid phosphodiester bond hydrolysis; cellular response to DNA damage stimulus; DNA repair; DNA duplex unwinding; positive regulation of protein monoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	57697
	104806
	ENSG00000187790
	ENSMUSG00000055884
	Q8IYD8
	Q8BGE5
	NM_001308133; NM_001308134; NM_020937
	NM_178912; NM_001364447
	NP_001295062; NP_001295063; NP_065988
	NP_849243; NP_001351376
	Wikidata
View/Edit Human	View/Edit Mouse

Fanconi anemia, complementation group M, also known as FANCM is a human gene. It is an emerging target in cancer therapy, in particular cancers with specific genetic deficiencies.