Fas ligand

FASLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MSV
Identifiers
Aliases	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand
External IDs	OMIM: 134638; MGI: 99255; HomoloGene: 533; GeneCards: FASLG; OMA:FASLG - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,666,876 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,616,064 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; lymph node; ; spleen; ; jejunal mucosa; ; mucosa of ileum; ; gallbladder; ; duodenum; ; rectum; ; bone marrow;
	Top expressed in
	blastocyst; ; lumbar subsegment of spinal cord; ; embryo; ; blood; ; embryo; ; spermatid; ; placenta; ; spleen; ; decidua; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding; tumor necrosis factor receptor binding; signaling receptor binding; death receptor binding;
Cellular component	integral component of membrane; membrane; cytoplasmic vesicle lumen; plasma membrane; integral component of plasma membrane; cell surface; lysosomal lumen; caveola; perinuclear region of cytoplasm; membrane raft; lysosome; extracellular exosome; cytoplasmic vesicle; nucleus; external side of plasma membrane; extracellular region; extracellular space;
Biological process	T cell apoptotic process; regulation of transcription, DNA-templated; cell-cell signaling; endosomal lumen acidification; negative regulation of transcription by RNA polymerase II; retinal cell programmed cell death; transcription, DNA-templated; response to lipopolysaccharide; positive regulation of neuron apoptotic process; positive regulation of endothelial cell apoptotic process; necroptotic signaling pathway; immune response; positive regulation of cell population proliferation; positive regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of angiogenesis; regulation of extrinsic apoptotic signaling pathway via death domain receptors; cellular chloride ion homeostasis; response to growth factor; inflammatory cell apoptotic process; positive regulation of epidermal growth factor receptor signaling pathway; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; extrinsic apoptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; necroptosis; apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic process; release of sequestered calcium ion into cytosol by endoplasmic reticulum; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	356
	14103
	ENSG00000117560
	ENSMUSG00000000817
	P48023
	P41047
	NM_001302746; NM_000639
	NM_001205243; NM_010177
	NP_000630; NP_001289675
	NP_001192172; NP_034307
	Wikidata
View/Edit Human	View/Edit Mouse

Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas receptor (CD95) to induce apoptosis, and also activates non-apoptotic pathways such as NF-κB and MAPK. FasL exists in membrane-bound and soluble forms, and is primarily expressed by cytotoxic T lymphocytes and natural killer cells. It plays a critical role in immune regulation, immune privilege, cancer, autoimmunity, and transplantation. The expression and function of FasL are tightly regulated to maintain immune homeostasis.