FASTKD2

FASTKD2
Identifiers
Aliases	FASTKD2, KIAA0971, FAST kinase domains 2, COXPD44
External IDs	OMIM: 612322; MGI: 1922869; HomoloGene: 8957; GeneCards: FASTKD2; OMA:FASTKD2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	206,796,189 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	63,793,814 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gastrocnemius muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; gonad; ; Achilles tendon; ; muscle of thigh; ; left ventricle; ; right ventricle; ; islet of Langerhans;
	Top expressed in
	Paneth cell; ; motor neuron; ; facial motor nucleus; ; soleus muscle; ; intercostal muscle; ; substantia nigra; ; fossa; ; cumulus cell; ; condyle; ; otic placode;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase activity; rRNA binding; RNA binding;
Cellular component	ribonucleoprotein granule; mitochondrial nucleoid; mitochondrion; nucleus; intercellular bridge;
Biological process	cellular respiration; protein phosphorylation; ribosome biogenesis; mitochondrial large ribosomal subunit assembly; positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
Orthologs
	22868
	75619
	ENSG00000118246
	ENSMUSG00000025962
	Q9NYY8
	Q922E6
	NM_014929; NM_001136193; NM_001136194
	NM_172422
	NP_001129665; NP_001129666; NP_055744
	NP_766010
	Wikidata
View/Edit Human	View/Edit Mouse

FAST kinase domain-containing protein 2 (FASTKD2) is a protein that in humans is encoded by the FASTKD2 gene on chromosome 2. This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress. FASTKD2 has been implicated in mitochondrial encephalomyopathy, breast cancer, and prostate cancer.