FBXL3

FBXL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4I6J
Identifiers
Aliases	FBXL3, FBL3, FBL3A, FBXL3A, F-box and leucine-rich repeat protein 3, F-box and leucine rich repeat protein 3, IDDSFAS
External IDs	OMIM: 605653; MGI: 1354702; HomoloGene: 8127; GeneCards: FBXL3; OMA:FBXL3 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	77,027,195 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	103,337,002 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; Achilles tendon; ; skin of arm; ; superficial temporal artery; ; skin of hip; ; trabecular bone; ; germinal epithelium; ; endothelial cell; ; skin of thigh; ; synovial joint;
	Top expressed in
	aortic valve; ; ascending aorta; ; neural layer of retina; ; granulocyte; ; lobe of cerebellum; ; muscle of thigh; ; cerebellar vermis; ; genital tubercle; ; tail of embryo; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; ubiquitin ligase complex; SCF ubiquitin ligase complex; nucleus; cytosol; nuclear body;
Biological process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; entrainment of circadian clock by photoperiod; regulation of circadian rhythm; protein destabilization; protein ubiquitination; rhythmic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	26224
	50789
	ENSG00000005812
	ENSMUSG00000022124
	Q9UKT7
	Q8C4V4
	NM_012158
	NM_015822; NM_001347600; NM_001347601; NM_001360341; NM_001360342
	NP_036290
	NP_001334529; NP_001334530; NP_056637; NP_001347270; NP_001347271
	Wikidata
View/Edit Human	View/Edit Mouse

FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3). FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex.

The FBXL3 protein participates in the negative feedback loop responsible for generating molecular circadian rhythms in mammals by binding to the CRY1 and CRY2 proteins to facilitate their polyubiquitination by the SCF complex and their subsequent degradation by the proteasome.