FBXL7

FBXL7
Identifiers
Aliases	FBXL7, FBL6, FBL7, F-box and leucine-rich repeat protein 7, F-box and leucine rich repeat protein 7
External IDs	OMIM: 605656; MGI: 3052506; HomoloGene: 69121; GeneCards: FBXL7; OMA:FBXL7 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	15,939,795 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	26,895,666 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; saphenous vein; ; urethra; ; tibia; ; vena cava; ; myocardium of left ventricle; ; embryo; ; myometrium; ; trigeminal ganglion;
	Top expressed in
	hand; ; vas deferens; ; lumbar spinal ganglion; ; gastrula; ; zygote; ; umbilical cord; ; genital tubercle; ; endocardial cushion; ; renal corpuscle; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity;
Cellular component	cytoplasm; ubiquitin ligase complex; microtubule organizing center; centrosome; SCF ubiquitin ligase complex; cytoskeleton; cytosol;
Biological process	cell division; cell cycle; cell population proliferation; G2/M transition of mitotic cell cycle; protein ubiquitination; ubiquitin-dependent protein catabolic process; protein polyubiquitination; SCF complex assembly; negative regulation of G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	23194
	448987
	ENSG00000183580
	ENSMUSG00000043556
	Q9UJT9
	Q5BJ29
	NM_001278317; NM_012304
	NM_176959
	NP_001265246; NP_036436
	NP_795933
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats.