FBXO6

FBXO6
Identifiers
Aliases	FBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6
External IDs	OMIM: 605647; MGI: 1354743; HomoloGene: 9274; GeneCards: FBXO6; OMA:FBXO6 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	11,674,354 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	148,236,597 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; muscle of thigh; ; gastrocnemius muscle; ; bronchial epithelial cell; ; blood; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; mucosa of ileum; ; right adrenal gland;
	Top expressed in
	urinary bladder; ; muscle of thigh; ; adrenal gland; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; placenta; ; white adipose tissue; ; lip; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; carbohydrate binding; ubiquitin-protein transferase activity; protein binding;
Cellular component	cytoplasm; SCF ubiquitin ligase complex; endoplasmic reticulum quality control compartment; cytosol;
Biological process	cellular response to DNA damage stimulus; DNA damage checkpoint signaling; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; DNA repair; protein ubiquitination; proteolysis; ubiquitin-dependent ERAD pathway; glycoprotein catabolic process; protein polyubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	26270
	50762
	ENSG00000116663
	ENSMUSG00000055401
	Q9NRD1
	Q9QZN4
	NM_018438
	NM_001163704; NM_001163705; NM_001163706; NM_001163707; NM_015797
	NP_060908
	NP_001157176; NP_001157177; NP_001157178; NP_001157179; NP_056612
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.