FBXO7

FBXO7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4L9C, 4L9H
Identifiers
Aliases	FBXO7, FBX, FBX07, FBX7, PARK15, PKPS, F-box protein 7
External IDs	OMIM: 605648; MGI: 1917004; HomoloGene: 8136; GeneCards: FBXO7; OMA:FBXO7 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	32,498,829 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	85,887,737 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; blood; ; sperm; ; corpus callosum; ; bone marrow; ; left lobe of thyroid gland; ; right testis; ; middle frontal gyrus; ; C1 segment; ; left testis;
	Top expressed in
	right kidney; ; otolith organ; ; utricle; ; blood; ; spermatocyte; ; proximal tubule; ; human kidney; ; sciatic nerve; ; hand; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity; protein kinase binding; ubiquitin protein ligase binding; ubiquitin binding; protein heterodimerization activity;
Cellular component	cytoplasm; ubiquitin ligase complex; mitochondrion; nucleus; cytosol; SCF ubiquitin ligase complex; glial cytoplasmic inclusion; classical Lewy body; Lewy neurite; Lewy body core; Lewy body corona; protein-containing complex;
Biological process	negative regulation of G1/S transition of mitotic cell cycle; protein targeting to mitochondrion; negative regulation of lymphocyte differentiation; autophagy of mitochondrion; regulation of protein stability; negative regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of locomotion; protein polyubiquitination; regulation of neuron projection development; protein ubiquitination; negative regulation of oxidative stress-induced neuron death; negative regulation of neuron death; positive regulation of autophagy of mitochondrion; negative regulation of hydrogen peroxide-induced neuron death; post-translational protein modification; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	25793
	69754
	ENSG00000100225
	ENSMUSG00000001786
	Q9Y3I1
	Q3U7U3
	NM_001033024; NM_001257990; NM_012179
	NM_153195; NM_001310745; NM_001347151
	NP_001028196; NP_001244919; NP_036311
	NP_001297674; NP_001334080; NP_694875
	Wikidata
View/Edit Human	View/Edit Mouse

F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene. Mutations in FBXO7 have been associated with Parkinson's disease.