FBXW11

FBXW11
Identifiers
Aliases	FBXW11, BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, F-box and WD repeat domain containing 11, NEDJED
External IDs	OMIM: 605651; MGI: 2144023; HomoloGene: 76444; GeneCards: FBXW11; OMA:FBXW11 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	172,006,873 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	32,696,816 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; islet of Langerhans; ; subthalamic nucleus; ; Brodmann area 23; ; cartilage tissue; ; pars compacta; ; superior vestibular nucleus; ; cerebellar vermis; ; endothelial cell;
	Top expressed in
	endocardial cushion; ; atrioventricular junction; ; atrioventricular valve; ; facial motor nucleus; ; Epithelium of choroid plexus; ; Rostral migratory stream; ; substantia nigra; ; left lung lobe; ; conjunctival fornix; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; ubiquitin protein ligase activity; protein binding; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; SCF ubiquitin ligase complex; nucleus; centrosome; ubiquitin ligase complex; cytosol;
Biological process	NIK/NF-kappaB signaling; Wnt signaling pathway; rhythmic process; cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle; protein dephosphorylation; stress-activated MAPK cascade; protein destabilization; positive regulation of circadian rhythm; proteasome-mediated ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-templated; protein ubiquitination; positive regulation of proteolysis; negative regulation of transcription, DNA-templated; protein polyubiquitination; post-translational protein modification; interleukin-1-mediated signaling pathway; negative regulation of NIK/NF-kappaB signaling; stimulatory C-type lectin receptor signaling pathway; Fc-epsilon receptor signaling pathway; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23291
	103583
	ENSG00000072803
	ENSMUSG00000020271
	Q9UKB1
	Q5SRY7
NM_012300; NM_033644; NM_033645; NM_001378974; NM_001378975;
	NM_001378976; NM_001378977; NM_001378978; NM_001378979; NM_001378980
NM_001271347; NM_001271348; NM_001271349; NM_134015; NM_001363353;
	NM_001363354; NM_001363355
NP_036432; NP_387448; NP_387449; NP_001365903; NP_001365904;
	NP_001365905; NP_001365906; NP_001365907; NP_001365908; NP_001365909
NP_001258276; NP_001258277; NP_001258278; NP_598776; NP_001350282;
	NP_001350283; NP_001350284
	Wikidata
View/Edit Human	View/Edit Mouse

βTrCP2 (beta-transducin repeat containing protein 2; also known as Fbxw11 or HOS) is a protein that in humans is encoded by the FBXW11 (F-box and WD repeat domain containing 11) gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 residue structural motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (Skp1-Cul1-F-box protein), which often, but not always, recognize substrates in a phosphorylation-dependent manner. F-box proteins are divided into 3 classes:

Fbxws containing WD40 repeats,
Fbxls containing leucine-rich repeats,
and Fbxos containing either "other" protein-protein interaction modules or no recognizable motifs.

The protein encoded by FBXW11 belongs to the Fbxw class as, in addition to an F-box, this protein contains multiple WD40 repeats. This protein is homologous to Xenopus βTrCP, yeast Met30, Neurospora Scon2 and Drosophila Slimb. In mammals, in addition to βTrCP2, a paralog protein (called βTrCP1 or FBXW1) also exists, but, so far, their functions appear redundant and indistinguishable.