FBXW8

FBXW8
Identifiers
Aliases	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6, F-box and WD repeat domain containing 8
External IDs	OMIM: 609073; MGI: 1923041; HomoloGene: 17731; GeneCards: FBXW8; OMA:FBXW8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	117,031,148 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	118,293,529 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gonad; ; ventricular zone; ; bone marrow cells; ; islet of Langerhans; ; ganglionic eminence; ; epithelium of colon; ; testicle; ; popliteal artery; ; tibial arteries;
	Top expressed in
	otic vesicle; ; otic placode; ; saccule; ; interventricular septum; ; internal carotid artery; ; external carotid artery; ; somite; ; calvaria; ; yolk sac; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity;
Cellular component	perinuclear region of cytoplasm; Golgi apparatus; Cul7-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; 3M complex; cytoplasm; cytosol;
Biological process	cell population proliferation; positive regulation of dendrite morphogenesis; spongiotrophoblast layer development; labyrinthine layer blood vessel development; Golgi organization; protein ubiquitination; protein polyubiquitination; post-translational protein modification; positive regulation of transcription factor catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26259
	231672
	ENSG00000174989
	ENSMUSG00000032867
	Q8N3Y1
	Q8BIA4
	NM_012174; NM_153348
	NM_172721
	NP_036306; NP_699179
	NP_766309
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 8 is a protein that in humans is encoded by the FBXW8 gene.

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin-protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.