FCN2

FCN2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2J0G, 2J0H, 2J0Y, 2J1G, 2J2P, 2J3F, 2J3G, 2J3O, 2J3U, 2J61, 4NYT, 4R9J, 4R9T
Identifiers
Aliases	FCN2, EBP-37, FCNL, P35, ficolin-2, ficolin 2
External IDs	OMIM: 601624; HomoloGene: 3031; GeneCards: FCN2; OMA:FCN2 - orthologs
RNA expression pattern
	Top expressed in
	right lobe of liver; ; spleen; ; pituitary gland; ; subcutaneous adipose tissue; ; prostate; ; right lobe of thyroid gland; ; kidney; ; anterior pituitary; ; minor salivary glands; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding; protein binding; mannan binding; metal ion binding; calcium-dependent protein binding; carbohydrate binding; proteoglycan binding; serine-type endopeptidase activity;
Cellular component	extracellular region; collagen; blood microparticle; extracellular exosome;
Biological process	immune system process; complement activation, lectin pathway; complement activation; recognition of apoptotic cell; opsonization; defense response to Gram-positive bacterium; innate immune response; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	2220
	n/a
	n/a
	n/a
	Q15485
	n/a
	NM_004108; NM_015837; NM_015838; NM_015839
	n/a
	NP_004099; NP_056652
	n/a
	Wikidata
View/Edit Human

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene.

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.