FERMT2

FERMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LGX, 2LKO, 2MSU, 4F7H
Identifiers
Aliases	FERMT2, KIND2, MIG2, PLEKHC1, UNC112, UNC112B, mig-2, fermitin family member 2, URP2SF, FERM domain containing kindlin 2
External IDs	OMIM: 607746; MGI: 2385001; HomoloGene: 4976; GeneCards: FERMT2; OMA:FERMT2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	52,952,435 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	45,767,575 bp
RNA expression pattern
	Top expressed in
	decidua; ; tail of epididymis; ; metanephric glomerulus; ; saphenous vein; ; cartilage tissue; ; parietal pleura; ; seminal vesicula; ; visceral pleura; ; tibia; ; secondary oocyte;
	Top expressed in
	left lung; ; left lung lobe; ; ankle; ; right lung lobe; ; vastus lateralis muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; tail of embryo; ; temporal muscle; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding; actin filament binding;
Cellular component	cytoplasm; filamentous actin; cytosol; cell projection; membrane; I band; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; stress fiber; nucleoplasm; cell surface; cell junction; cell cortex; cytoskeleton; lamellipodium membrane; nucleus;
Biological process	protein localization to membrane; Wnt signaling pathway; focal adhesion assembly; cell adhesion; regulation of cell shape; integrin-mediated signaling pathway; substrate adhesion-dependent cell spreading; integrin activation; cell-matrix adhesion; transforming growth factor beta receptor signaling pathway; cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	10979
	218952
	ENSG00000073712
	ENSMUSG00000037712
	Q96AC1
	Q8CIB5
	NM_001134999; NM_001135000; NM_006832
	NM_146054; NM_001360525; NM_001360526
	NP_001128471; NP_001128472; NP_006823
	NP_666166; NP_001347454; NP_001347455
	Wikidata
View/Edit Human	View/Edit Mouse

Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.

Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein.