FERM domain
| FERM N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein. | |||||||||
| Identifiers | |||||||||
| Symbol | FERM_N | ||||||||
| Pfam | PF09379 | ||||||||
| Pfam clan | CL0072 | ||||||||
| InterPro | IPR018979 | ||||||||
| SCOP2 | 1gc7 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 49 | ||||||||
| OPM protein | 1gc6 | ||||||||
| Membranome | 161 | ||||||||
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| FERM central domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the protein 4.1r membrane binding domain | |||||||||
| Identifiers | |||||||||
| Symbol | FERM_M | ||||||||
| Pfam | PF00373 | ||||||||
| InterPro | IPR019748 | ||||||||
| SCOP2 | 1gc7 / SCOPe / SUPFAM | ||||||||
| CDD | cd14473 | ||||||||
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| FERM C-terminal PH-like domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
crystal structure of the radixin ferm domain complexed with the nep cytoplasmic tail | |||||||||
| Identifiers | |||||||||
| Symbol | FERM_C | ||||||||
| Pfam | PF09380 | ||||||||
| Pfam clan | CL0266 | ||||||||
| InterPro | IPR018980 | ||||||||
| SCOP2 | 1ef1 / SCOPe / SUPFAM | ||||||||
| CDD | cd00836 | ||||||||
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In molecular biology, the FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus in the majority of proteins in which it is found.