FER (gene)

FER
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KK6
Identifiers
Aliases	FER, FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3, p94-Fer, FER tyrosine kinase
External IDs	OMIM: 176942; MGI: 105917; HomoloGene: 74300; GeneCards: FER; OMA:FER - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	109,196,841 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	64,446,491 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; secondary oocyte; ; buccal mucosa cell; ; sural nerve; ; sperm; ; tendon of biceps brachii; ; corpus callosum; ; epithelium of colon; ; internal globus pallidus; ; testicle;
	Top expressed in
	spermatid; ; otic placode; ; spermatocyte; ; saccule; ; primary oocyte; ; secondary oocyte; ; esophagus; ; tail of embryo; ; zygote; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; epidermal growth factor receptor binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein phosphatase 1 binding; protein binding; protein tyrosine kinase activity; ATP binding; lipid binding;
Cellular component	cytoplasm; cell projection; membrane; microtubule cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; cell junction; cell cortex; actin cytoskeleton; cytoskeleton; nucleus; lamellipodium; cytosol;
Biological process	regulation of protein phosphorylation; regulation of lamellipodium assembly; actin cytoskeleton reorganization; diapedesis; cell differentiation; intracellular signal transduction; positive regulation of actin filament polymerization; extracellular matrix-cell signaling; phosphorylation; cytokine-mediated signaling pathway; Kit signaling pathway; positive regulation of cell migration; regulation of epidermal growth factor receptor signaling pathway; response to platelet-derived growth factor; cellular response to macrophage colony-stimulating factor stimulus; cell-cell adhesion mediated by cadherin; cellular response to reactive oxygen species; chemotaxis; protein phosphorylation; Fc-epsilon receptor signaling pathway; interleukin-6-mediated signaling pathway; response to lipopolysaccharide; cell adhesion; positive regulation of NF-kappaB transcription factor activity; positive regulation of cell population proliferation; insulin receptor signaling pathway via phosphatidylinositol 3-kinase; cellular response to insulin stimulus; mitotic cell cycle; peptidyl-tyrosine autophosphorylation; negative regulation of mast cell activation involved in immune response; protein autophosphorylation; peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading; regulation of mast cell degranulation; platelet-derived growth factor receptor signaling pathway; cell population proliferation; regulation of fibroblast migration; innate immune response; microtubule cytoskeleton organization; signal transduction; tyrosine phosphorylation of STAT protein; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	2241
	14158
	ENSG00000151422
	ENSMUSG00000000127
	P16591
	P70451
	NM_001308028; NM_001308031; NM_001308038; NM_005246
	NM_001037997; NM_001286415; NM_008000
	NP_001294957; NP_001294960; NP_001294967; NP_005237
	NP_001033086; NP_001273344; NP_032026
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene.

Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors.