FEZ1

FEZ1
Identifiers
Aliases	FEZ1, UNC-76, fasciculation and elongation protein zeta 1
External IDs	OMIM: 604825; MGI: 2670976; HomoloGene: 21063; GeneCards: FEZ1; OMA:FEZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	125,592,568 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	36,790,220 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; C1 segment; ; inferior ganglion of vagus nerve; ; corpus callosum; ; middle frontal gyrus; ; subthalamic nucleus; ; prefrontal cortex; ; Pons; ; dorsal motor nucleus of vagus nerve; ; substantia nigra;
	Top expressed in
	deep cerebellar nuclei; ; globus pallidus; ; ventricular zone; ; lobe of cerebellum; ; cerebellar vermis; ; inferior colliculi; ; superior colliculus; ; lateral geniculate nucleus; ; ganglionic eminence; ; Medulla Oblongata;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; gamma-tubulin binding; protein kinase C binding; protein N-terminus binding;
Cellular component	centrosome; Golgi apparatus; cell projection; membrane; plasma membrane; microtubule organizing center; dendrite; mitochondrion; microtubule; cytoskeleton; cytoplasm; axon; growth cone; soma; microtubule cytoskeleton;
Biological process	negative regulation of autophagosome assembly; cellular response to growth factor stimulus; nervous system development; axon guidance; cell adhesion; establishment of mitochondrion localization; positive regulation of neuron differentiation; positive regulation of neuron projection development; hippocampus development; establishment of cell polarity; positive regulation of anterograde axonal transport of mitochondrion; mitochondrion morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9638
	235180
	ENSG00000149557
	ENSMUSG00000032118
	Q99689
	Q8K0X8
	NM_005103; NM_022549
NM_183171; NM_001357610; NM_001357611; NM_001357612; NM_001357613;
	NM_001357614
	NP_005094; NP_072043
NP_898994; NP_001344539; NP_001344540; NP_001344541; NP_001344542;
	NP_001344543
	Wikidata
View/Edit Human	View/Edit Mouse

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.