FEZ2

FEZ2
Identifiers
Aliases	FEZ2, HUM3CL, fasciculation and elongation protein zeta 2
External IDs	OMIM: 604826; MGI: 2675856; HomoloGene: 3742; GeneCards: FEZ2; OMA:FEZ2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	36,646,087 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	78,725,581 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; thoracic diaphragm; ; deltoid muscle; ; parietal pleura; ; muscle of thigh; ; visceral pleura; ; Brodmann area 23;
	Top expressed in
	epithelium of lens; ; sternocleidomastoid muscle; ; muscle of thigh; ; triceps brachii muscle; ; retinal pigment epithelium; ; right ventricle; ; temporal muscle; ; quadriceps femoris muscle; ; digastric muscle; ; gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; axon;
Biological process	signal transduction; nervous system development; negative regulation of autophagosome assembly; axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	9637
	225020
	ENSG00000171055
	ENSMUSG00000056121
	Q9UHY8
	Q6TYB5
	NM_001042548; NM_005102
	NM_001285940; NM_001285946; NM_001285949; NM_199448; NM_001360407
	NP_001036013; NP_005093
	NP_001272869; NP_001272875; NP_001272878; NP_955519; NP_001347336
	Wikidata
View/Edit Human	View/Edit Mouse

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene.

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin.