FGF12

FGF12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Q1U, 4JQ0
Identifiers
Aliases	FGF12, FGF12B, FHF1, fibroblast growth factor 12, EIEE47, DEE47
External IDs	OMIM: 601513; MGI: 109183; HomoloGene: 10874; GeneCards: FGF12; OMA:FGF12 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	192,767,764 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	28,571,820 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; cardiac muscle tissue of right atrium; ; apex of heart; ; Pons; ; myocardium of left ventricle; ; right ventricle; ; right adrenal cortex; ; left adrenal cortex; ; middle temporal gyrus; ; prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; medial dorsal nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; medial geniculate nucleus; ; pontine nuclei; ; anterior horn of spinal cord; ; lateral septal nucleus; ; lateral geniculate nucleus; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; heparin binding; transmembrane transporter binding; fibroblast growth factor receptor binding; protein binding; growth factor activity;
Cellular component	nucleus; intracellular anatomical structure; extracellular space;
Biological process	negative regulation of cation channel activity; adult locomotory behavior; cell-cell signaling; cardiac muscle cell action potential involved in contraction; regulation of membrane depolarization; nervous system development; fibroblast growth factor receptor signaling pathway; JNK cascade; heart development; neuromuscular process; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; regulation of sodium ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of voltage-gated sodium channel activity; regulation of neuronal action potential; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	2257
	14167
	ENSG00000114279
	ENSMUSG00000022523
	P61328
	P61329
	NM_004113; NM_021032; NM_001377292; NM_001377293; NM_001377294
	NM_001276419; NM_001276420; NM_010199; NM_183064; NM_001357064
	NP_004104; NP_066360; NP_001364221; NP_001364222; NP_001364223
	NP_001263348; NP_001263349; NP_034329; NP_898887; NP_001343993
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.