FGF17

FGF17
Identifiers
Aliases	FGF17, FGF-13, HH20, FGF-17, fibroblast growth factor 17
External IDs	OMIM: 603725; MGI: 1202401; HomoloGene: 2872; GeneCards: FGF17; OMA:FGF17 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,048,809 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,642,268 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; testicle; ; anterior cingulate cortex; ; Brodmann area 9; ; gonad; ; nucleus accumbens; ; Amygdala; ; right lobe of thyroid gland; ; caudate nucleus;
	Top expressed in
	tail of embryo; ; lumbar subsegment of spinal cord; ; medial nasal prominence; ; embryo; ; embryo; ; vasculature of trunk; ; gray matter layer of cerebellum; ; pulmonary artery; ; descending aorta; ; Descending thoracic aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	cell-cell signaling; nervous system development; MAPK cascade; multicellular organism development; fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; signal transduction; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	8822
	14171
	ENSG00000158815
	ENSMUSG00000022101
	O60258
	P63075
	NM_001304478; NM_003867
	NM_008004; NM_001360108
	NP_001291407; NP_003858
	NP_032030; NP_001347037
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development. This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17.