Fibroblast growth factor 18

FGF18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CJM
Identifiers
Aliases	FGF18, FGF-18, ZFGF5, fibroblast growth factor 18
External IDs	OMIM: 603726; MGI: 1277980; HomoloGene: 2867; GeneCards: FGF18; OMA:FGF18 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	171,457,626 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,097,400 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right ventricle; ; vena cava; ; myocardium of left ventricle; ; cartilage tissue; ; apex of heart; ; buccal mucosa cell; ; parietal pleura; ; gonad; ; endothelial cell;
	Top expressed in
	tail of embryo; ; internal carotid artery; ; aortic valve; ; external carotid artery; ; hair; ; facial motor nucleus; ; deep cerebellar nuclei; ; coronal suture; ; trigeminal ganglion; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; nucleolus; extracellular space;
Biological process	intramembranous ossification; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of sprouting angiogenesis; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of MAP kinase activity; ossification; lung development; cell-cell signaling; anatomical structure morphogenesis; chondrocyte development; endochondral ossification; MAPK cascade; fibroblast growth factor receptor signaling pathway; positive regulation of chondrocyte differentiation; angiogenesis; positive regulation of cell population proliferation; regulation of endothelial cell proliferation; signal transduction; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	8817
	14172
	ENSG00000156427
	ENSMUSG00000057967
	O76093
	O89101
	NM_033649; NM_003862
	NM_008005
	NP_003853
	NP_032031
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18. Subsequent studies identified FGF18's role in promoting chondrogenesis, and an apparent specific activity for the generation of the hyaline cartilage in articular joints.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, and tissue repair. It has been shown in vitro that this protein is able to induce the outgrowth of neurites in PC12 cells.