FGF19

FGF19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PWA, 2P23
Identifiers
Aliases	FGF19, fibroblast growth factor 19
External IDs	OMIM: 603891; MGI: 1096383; HomoloGene: 3754; GeneCards: FGF19; OMA:FGF19 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,704,022 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,900,953 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; gonad; ; islet of Langerhans; ; sural nerve; ; small intestine; ; mucosa of small intestine; ; duodenum; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	gray matter layer of cerebellum; ; dorsal nucleus of lateral geniculate body; ; Purkinje cell; ; embryo; ; embryo; ; primitive streak; ; tail of embryo; ; epiblast; ; medial habenular nucleus; ; pretectal area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; protein binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure;
Biological process	positive regulation of glucose import; positive regulation of protein phosphorylation; positive regulation of JNK cascade; negative regulation of gene expression; nervous system development; MAPK cascade; fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; neural crest cell migration; heart development; negative regulation of bile acid biosynthetic process; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	9965
	14170
	ENSG00000162344
	ENSMUSG00000031073
	O95750
	O35622
	NM_005117
	NM_008003
	NP_005108
	NP_032029
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.