Fibroblast growth factor 23

FGF23
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2P39
Identifiers
Aliases	FGF23, ADHR, FGFN, HPDR2, HYPF, PHPTC, fibroblast growth factor 23, HFTC2
External IDs	OMIM: 605380; MGI: 1891427; HomoloGene: 10771; GeneCards: FGF23; OMA:FGF23 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,379,712 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	127,058,371 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; gonad; ; testicle; ; right auricle of heart; ; liver; ; right lobe of liver; ; muscle of thigh; ; muscle tissue; ; primary visual cortex; ; blood;
	Top expressed in
	embryo; ; lumbar spinal ganglion; ; zygote; ; lumbar subsegment of spinal cord; ; tibiofemoral joint; ; superior frontal gyrus; ; extraocular muscle; ; vastus lateralis muscle; ; carotid body; ; major salivary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; protein binding;
Cellular component	extracellular region; Golgi lumen; endoplasmic reticulum lumen; extracellular space;
Biological process	cell differentiation; negative regulation of bone mineralization; cellular response to interleukin-6; vitamin D metabolic process; regulation of bone mineralization; phosphate ion homeostasis; cellular phosphate ion homeostasis; response to magnesium ion; regulation of phosphate transport; cellular response to vitamin D; negative regulation of osteoblast differentiation; cellular response to leptin stimulus; positive regulation of transcription, DNA-templated; fibroblast growth factor receptor signaling pathway; response to sodium phosphate; positive regulation of ERK1 and ERK2 cascade; positive regulation of vitamin D 24-hydroxylase activity; phosphate-containing compound metabolic process; vitamin D catabolic process; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; cellular response to parathyroid hormone stimulus; negative regulation of hormone secretion; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; MAPK cascade; post-translational protein modification; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	8074
	64654
	ENSG00000118972
	ENSMUSG00000000182
	Q9GZV9
	Q9EPC2
	NM_020638
	NM_022657
	NP_065689
	NP_073148
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF-23 decreases reabsorption of phosphate in the kidney. Mutations in FGF23 can lead to its increased activity, resulting in autosomal dominant hypophosphatemic rickets.