FGF6

FGF6
Identifiers
Aliases	FGF6, HBGF-6, HST2, fibroblast growth factor 6
External IDs	OMIM: 134921; MGI: 95520; HomoloGene: 10870; GeneCards: FGF6; OMA:FGF6 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,445,815 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	127,005,150 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; oocyte; ; external globus pallidus; ; pars compacta; ; secondary oocyte; ; superior frontal gyrus; ; duodenum; ; urinary bladder;
	Top expressed in
	triceps brachii muscle; ; myotome; ; ankle; ; temporal muscle; ; elbow; ; tongue muscle; ; soleus muscle; ; tibialis anterior muscle; ; sternocleidomastoid muscle; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; sarcolemma; intracellular anatomical structure; extracellular space;
Biological process	cell differentiation; cell-cell signaling; MAPK cascade; multicellular organism development; fibroblast growth factor receptor signaling pathway; angiogenesis; positive regulation of cell population proliferation; cell population proliferation; myoblast differentiation; positive regulation of cell division; cartilage condensation; signal transduction; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	2251
	14177
	ENSG00000111241
	ENSMUSG00000000183
	P10767
	P21658
	NM_020996
	NM_010204
	NP_066276
	NP_034334
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.