FGR (gene)

FGR
Identifiers
Aliases	FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 164940; MGI: 95527; HomoloGene: 3842; GeneCards: FGR; OMA:FGR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,635,185 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,729,221 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; right lung; ; spleen; ; upper lobe of left lung; ; bone marrow cells; ; trabecular bone; ; appendix; ; lower lobe of lung;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; blood; ; spleen; ; bone marrow; ; mesenteric lymph nodes; ; lumbar subsegment of spinal cord; ; oocyte; ; secondary oocyte; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; immunoglobulin receptor binding; kinase activity; protein binding; Fc-gamma receptor I complex binding; ATP binding; protein kinase binding; protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding; signaling receptor binding;
Cellular component	cytoplasm; cytosol; cell projection; membrane; extrinsic component of cytoplasmic side of plasma membrane; mitochondrial intermembrane space; ruffle membrane; mitochondrion; actin cytoskeleton; mitochondrial inner membrane; extracellular exosome; cytoskeleton; extracellular region; plasma membrane; aggresome; secretory granule lumen;
Biological process	cell differentiation; regulation of innate immune response; Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; immune system process; positive regulation of cell migration; response to virus; positive regulation of mast cell degranulation; immune response-regulating cell surface receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; regulation of cell population proliferation; regulation of cell shape; peptidyl-tyrosine autophosphorylation; integrin-mediated signaling pathway; protein autophosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; regulation of protein kinase activity; regulation of phagocytosis; defense response to Gram-positive bacterium; cell migration; innate immune response; neutrophil degranulation; bone mineralization; skeletal system morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	2268
	14191
	ENSG00000000938
	ENSMUSG00000028874
	P09769
	P14234
	NM_001042729; NM_001042747; NM_005248
	NM_010208
	NP_001036194; NP_001036212; NP_005239
	NP_034338
	Wikidata
View/Edit Human	View/Edit Mouse

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.