FIP1L1

FIP1L1
Identifiers
Aliases	FIP1L1, FIP1, Rhe, hFip1, factor interacting with PAPOLA and CPSF1
External IDs	OMIM: 607686; MGI: 1914149; HomoloGene: 134000; GeneCards: FIP1L1; OMA:FIP1L1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	53,460,862 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	74,759,461 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; Achilles tendon; ; gonad; ; left testis; ; sural nerve; ; right testis; ; ventricular zone; ; left ovary; ; ganglionic eminence; ; internal globus pallidus;
	Top expressed in
	primary oocyte; ; saccule; ; tail of embryo; ; secondary oocyte; ; zygote; ; genital tubercle; ; aortic valve; ; otic vesicle; ; supraoptic nucleus; ; otic placode;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	nucleus; nucleoplasm; mRNA cleavage and polyadenylation specificity factor complex;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; mRNA export from nucleus; mRNA polyadenylation; pre-mRNA cleavage required for polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	81608
	66899
	ENSG00000145216
	ENSMUSG00000029227
	Q6UN15
	Q9D824
	NM_001134937; NM_001134938; NM_030917
	NM_001159573; NM_001159574; NM_024183; NM_001376964; NM_001376965
NP_001128409; NP_001128410; NP_112179; NP_001363673; NP_001363674;
	NP_001363675; NP_001363676; NP_001363677; NP_001363678; NP_001363679; NP_001363680; NP_001363681; NP_001363682; NP_001363683; NP_001363684; NP_001363685; NP_001363686; NP_001363687; NP_001363688; NP_001363689; NP_001363690; NP_001363691; NP_001363693; NP_001363694; NP_001363695; NP_001363696; NP_001363697; NP_001363698; NP_001363699; NP_001363700; NP_001363701; NP_001363702; NP_001363703; NP_001363704; NP_001363705; NP_001363706; NP_001363707; NP_001363708; NP_001363709; NP_001363710; NP_001363711; NP_001363712; NP_001363713; NP_001363714; NP_001363715
	NP_001153045; NP_001153046; NP_077145; NP_001363893; NP_001363894
	Wikidata
View/Edit Human	View/Edit Mouse

Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). A medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause clonal hypereosinophilia and leukemic diseases in humans.