FIS1

FIS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NZN, 1PC2
Identifiers
Aliases	FIS1, TTC11, CGI-135, fission, mitochondrial 1
External IDs	OMIM: 609003; MGI: 1913687; HomoloGene: 41099; GeneCards: FIS1; OMA:FIS1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	101,252,316 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,995,088 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; apex of heart; ; prefrontal cortex; ; muscle of thigh; ; anterior pituitary; ; gastrocnemius muscle; ; anterior cingulate cortex; ; right frontal lobe; ; right auricle of heart; ; left ventricle;
	Top expressed in
	interventricular septum; ; blood; ; granulocyte; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; visual cortex; ; lip; ; primary visual cortex; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling receptor binding; protein-containing complex binding;
Cellular component	integral component of membrane; membrane; peroxisomal membrane; peroxisome; mitochondrial outer membrane; mitochondrion; integral component of peroxisomal membrane; endoplasmic reticulum; integral component of mitochondrial outer membrane; protein-containing complex;
Biological process	mitochondrial fusion; mitochondrial fission; regulation of mitochondrion organization; positive regulation of cytosolic calcium ion concentration; protein targeting to mitochondrion; peroxisome fission; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; autophagy of mitochondrion; negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of mitochondrial calcium ion concentration; mitochondrion morphogenesis; calcium-mediated signaling using intracellular calcium source; positive regulation of intrinsic apoptotic signaling pathway; release of cytochrome c from mitochondria; positive regulation of protein targeting to membrane; apoptotic process; response to muscle activity; cellular response to glucose stimulus; cellular response to toxic substance; response to hypobaric hypoxia; positive regulation of neuron apoptotic process; mitochondrial fragmentation involved in apoptotic process; protein homooligomerization; cellular response to lipid; positive regulation of mitochondrial fission; cellular response to peptide; response to flavonoid; response to nutrient levels; response to fluoride;
	Sources:Amigo / QuickGO
Orthologs
	51024
	66437
	ENSG00000214253
	ENSMUSG00000019054
	Q9Y3D6
	Q9CQ92
	NM_016068
	NM_001163243; NM_025562; NM_001347504
	NP_057152
	NP_001156715; NP_001334433; NP_079838
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. This protein is a component of a mitochondrial complex, the ARCosome, that promotes mitochondrial fission. Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell cycle, and apoptosis. By extension, the protein is involved in associated diseases, including neurodegenerative diseases and cancers.