FKBP1A

FKBP1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A7X, 1B6C, 1BKF, 1BL4, 1D6O, 1D7H, 1D7I, 1D7J, 1EYM, 1F40, 1FAP, 1FKB, 1FKD, 1FKF, 1FKG, 1FKH, 1FKI, 1FKJ, 1FKR, 1FKS, 1FKT, 1J4H, 1J4I, 1J4R, 1NSG, 1QPF, 1QPL, 2DG3, 2DG4, 2DG9, 2FAP, 2FKE, 2PPN, 2PPO, 2PPP, 2RSE, 3FAP, 3H9R, 3MDY, 4DH0, 4FAP, 4IPX, 4N19, 4ODP, 4ODQ, 4ODR
Identifiers
Aliases	FKBP1A, FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE, FK506 binding protein 1A, FKBP prolyl isomerase 1A
External IDs	OMIM: 186945; MGI: 95541; HomoloGene: 105139; GeneCards: FKBP1A; OMA:FKBP1A - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,393,164 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	151,403,612 bp
RNA expression pattern
	Top expressed in
	right lung; ; monocyte; ; upper lobe of left lung; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; nucleus accumbens; ; epithelium of colon; ; rectum; ; left uterine tube; ; smooth muscle tissue;
	Top expressed in
	lateral septal nucleus; ; olfactory tubercle; ; external carotid artery; ; internal carotid artery; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; nucleus accumbens; ; anterior amygdaloid area; ; endocardial cushion; ; Gonadal ridge;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium channel inhibitor activity; activin binding; isomerase activity; macrolide binding; peptidyl-prolyl cis-trans isomerase activity; signal transducer activity; protein binding; SMAD binding; transforming growth factor beta receptor binding; FK506 binding; enzyme binding; Hsp70 protein binding; type I transforming growth factor beta receptor binding; protein homodimerization activity; transmembrane transporter binding;
Cellular component	cytoplasm; terminal cisterna; Z discdkac; extracellular exosome; extrinsic component of organelle membrane; cytoplasmic side of membrane; ryanodine receptor complex; cytosol; membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; intracellular membrane-bounded organelle; axon terminus;
Biological process	SMAD protein complex assembly; amyloid fibril formation; regulation of activin receptor signaling pathway; protein maturation by protein folding; regulation of amyloid precursor protein catabolic process; protein peptidyl-prolyl isomerization; negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of protein localization; calcium ion transmembrane transport; protein refolding; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of protein binding; positive regulation of protein ubiquitination; 'de novo' protein folding; transforming growth factor beta receptor signaling pathway; T cell activation; chaperone-mediated protein folding; supramolecular fiber organization; negative regulation of phosphoprotein phosphatase activity; protein folding; negative regulation of protein phosphorylation; heart morphogenesis; muscle contraction; response to iron ion; cytokine-mediated signaling pathway; response to caffeine; T cell proliferation; release of sequestered calcium ion into cytosol; ventricular cardiac muscle tissue morphogenesis; regulation of ryanodine-sensitive calcium-release channel activity; heart trabecula formation;
	Sources:Amigo / QuickGO
Orthologs
	2280
	14225
	ENSG00000088832
	ENSMUSG00000032966
	P62942
	P26883
	NM_054014; NM_000801; NM_001199786
NM_001302077; NM_001302078; NM_001302079; NM_001302080; NM_008019;
	NM_001355077; NM_001355078
	NP_000792; NP_001186715; NP_463460
NP_001289006; NP_001289007; NP_001289008; NP_001289009; NP_032045;
	NP_001342006; NP_001342007
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene. It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins (FKBPs).