FKBP8

FKBP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AWG, 2D9F, 2F2D, 2MF9, 3EY6
Identifiers
Aliases	FKBP8, FKBP38, FKBPr38, FK506 binding protein 8, FKBP prolyl isomerase 8
External IDs	OMIM: 604840; MGI: 1341070; HomoloGene: 7720; GeneCards: FKBP8; OMA:FKBP8 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,544,077 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,987,978 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; anterior pituitary; ; C1 segment; ; cingulate gyrus; ; anterior cingulate cortex; ; muscle layer of sigmoid colon; ; right uterine tube;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; spermatocyte; ; neural layer of retina; ; granulocyte; ; lip; ; perirhinal cortex; ; entorhinal cortex; ; ventricular zone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; metal ion binding; protein binding; identical protein binding; disordered domain specific binding;
Cellular component	integral component of membrane; membrane; mitochondrial membranes; integral component of endoplasmic reticulum membrane; mitochondrial envelope; mitochondrion; endoplasmic reticulum; cytosol; cytoplasm; protein-containing complex;
Biological process	apoptotic process; intracellular signal transduction; multicellular organism growth; cell fate specification; negative regulation of apoptotic process; regulation of BMP signaling pathway; neural tube development; positive regulation of BMP signaling pathway; regulation of gene expression; smoothened signaling pathway; camera-type eye development; dorsal/ventral neural tube patterning; viral process; dorsal/ventral pattern formation; chaperone-mediated protein folding; protein peptidyl-prolyl isomerization; negative regulation of protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23770
	14232
	ENSG00000105701
	ENSMUSG00000019428
	Q14318
	O35465
	NM_001308373; NM_012181
	NM_001111066; NM_001199631; NM_010223
	NP_001295302; NP_036313; NP_001295302.1
	NP_001104536; NP_001186560; NP_034353
	Wikidata
View/Edit Human	View/Edit Mouse

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.