FLNC (gene)

FLNC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V05, 2D7M, 2D7N, 2D7O, 2D7P, 2D7Q, 2K9U, 2NQC, 3V8O, 4MGX
Identifiers
Aliases	FLNC, ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4, filamin C, RCM5, CMH26
External IDs	OMIM: 102565; MGI: 95557; HomoloGene: 37481; GeneCards: FLNC; OMA:FLNC - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,859,274 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	29,461,882 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; tibialis anterior muscle; ; apex of heart; ; glutes; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; left ventricle; ; triceps brachii muscle;
	Top expressed in
	muscle of thigh; ; temporal muscle; ; soleus muscle; ; gastrula; ; ankle; ; medial head of gastrocnemius muscle; ; skeletal muscle tissue; ; digastric muscle; ; tibialis anterior muscle; ; masseter muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; actin binding; cytoskeletal protein binding; protein binding; ankyrin binding; identical protein binding;
Cellular component	Z discdkac; sarcolemma; plasma membrane; membrane; focal adhesion; sarcoplasm; cytoplasm; costamere; cytoskeleton; cytosol;
Biological process	cell junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	2318
	68794
	ENSG00000128591
	ENSMUSG00000068699
	Q14315
	Q8VHX6
	NM_001458; NM_001127487
	NM_001081185; NM_001311074; NM_026839
	NP_001120959; NP_001449
	NP_001074654; NP_001298003
	Wikidata
View/Edit Human	View/Edit Mouse

Filamin-C (FLN-C) also known as actin-binding-like protein (ABPL) or filamin-2 (FLN2) is a protein that in humans is encoded by the FLNC gene. Filamin-C is mainly expressed in cardiac and skeletal muscles, and functions at Z-discs and in subsarcolemmal regions.