FLOT1

FLOT1
Identifiers
Aliases	FLOT1, flotillin 1
External IDs	OMIM: 606998; MGI: 1100500; HomoloGene: 31337; GeneCards: FLOT1; OMA:FLOT1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,742,732 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,143,683 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; apex of heart; ; blood; ; C1 segment; ; dorsolateral prefrontal cortex; ; left ventricle; ; Cerebellum;
	Top expressed in
	granulocyte; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; right ventricle; ; dentate gyrus of hippocampal formation granule cell; ; ankle joint; ; sciatic nerve; ; facial motor nucleus; ; spinal ganglia; ; visual cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; protein heterodimerization activity; ionotropic glutamate receptor binding;
Cellular component	integral component of membrane; endosome; membrane; cell-cell contact zone; focal adhesion; plasma membrane raft; melanosome; plasma membrane; centriolar satellite; microtubule organizing center; lysosomal membrane; flotillin complex; uropod; basolateral plasma membrane; early endosome; apical plasma membrane; cortical actin cytoskeleton; caveola; membrane raft; COP9 signalosome; sarcolemma; extracellular exosome; cytoplasmic vesicle; lamellipodium; cell-cell junction; external side of plasma membrane; synapse; presynaptic active zone; dopaminergic synapse; presynapse; glutamatergic synapse; GABA-ergic synapse;
Biological process	positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cell adhesion molecule production; positive regulation of protein phosphorylation; regulation of toll-like receptor 4 signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of toll-like receptor 3 signaling pathway; axonogenesis; positive regulation of skeletal muscle tissue development; positive regulation of cytokine production; extracellular matrix disassembly; protein kinase C signaling; response to endoplasmic reticulum stress; positive regulation of myoblast fusion; positive regulation of endocytosis; positive regulation of cell junction assembly; protein localization to membrane raft; membrane raft assembly; cellular response to exogenous dsRNA; regulation of receptor internalization; positive regulation of synaptic transmission, dopaminergic; positive regulation of protein binding; regulation of Rho protein signal transduction; protein homooligomerization; dsRNA transport; plasma membrane raft assembly; positive regulation of interferon-beta production; protein stabilization; protein localization to plasma membrane; regulation of neurotransmitter uptake; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	10211
	14251
ENSG00000137312; ENSG00000232280; ENSG00000224740; ENSG00000206480; ENSG00000206379;
	ENSG00000230143; ENSG00000236271; ENSG00000223654
	ENSMUSG00000059714
	O75955
	O08917
	NM_005803; NM_001318875
	NM_008027
	NP_001305804; NP_005794
	NP_032053
	Wikidata
View/Edit Human	View/Edit Mouse

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.