FLOT2

FLOT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WIN
Identifiers
Aliases	FLOT2, ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
External IDs	OMIM: 131560; MGI: 103309; HomoloGene: 3293; GeneCards: FLOT2; OMA:FLOT2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,897,733 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	77,951,260 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; spleen; ; blood; ; gastric mucosa; ; apex of heart; ; olfactory zone of nasal mucosa; ; lymph node; ; minor salivary glands; ; right lung;
	Top expressed in
	ankle joint; ; external carotid artery; ; facial motor nucleus; ; internal carotid artery; ; tunica media of zone of aorta; ; granulocyte; ; dorsomedial hypothalamic nucleus; ; motor neuron; ; carotid body; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protease binding; protein binding; protein heterodimerization activity; ionotropic glutamate receptor binding;
Cellular component	vesicle; endosome; membrane; cell-cell contact zone; focal adhesion; endocytic vesicle; acrosomal membrane; flotillin complex; uropod; basolateral plasma membrane; apical plasma membrane; cortical actin cytoskeleton; perinuclear region of cytoplasm; caveola; membrane raft; extracellular exosome; cytoplasmic vesicle; lamellipodium; plasma membrane; dendrite cytoplasm; synapse; glutamatergic synapse; anchored component of presynaptic active zone membrane;
Biological process	positive regulation of establishment of T cell polarity; regulation of toll-like receptor 3 signaling pathway; regulation of heterotypic cell-cell adhesion; protein stabilization; negative regulation of amyloid precursor protein catabolic process; negative regulation of gene expression; protein localization to plasma membrane raft; cell adhesion; membrane raft assembly; regulation of myoblast differentiation; epidermis development; protein localization to plasma membrane; anterograde dendritic transport; regulation of postsynaptic membrane neurotransmitter receptor levels; positive regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	2319
	14252
	ENSG00000132589
	ENSMUSG00000061981
	Q14254
	Q60634
	NM_004475; NM_001330170
NM_001040403; NM_001284227; NM_001284228; NM_008028; NM_001362625;
	NM_001362626; NM_001362627
	NP_001317099; NP_004466
NP_001035493; NP_001271156; NP_001271157; NP_032054; NP_001349554;
	NP_001349555; NP_001349556
	Wikidata
View/Edit Human	View/Edit Mouse

Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.