FLT4

FLT4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BSJ, 4BSK
Identifiers
Aliases	FLT4, FLT41, LMPH1A, PCL, VEGFR3, FLT-4, VEGFR-3, fms related tyrosine kinase 4, LMPHM1, fms related receptor tyrosine kinase 4, CHTD7
External IDs	OMIM: 136352; MGI: 95561; HomoloGene: 7321; GeneCards: FLT4; OMA:FLT4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	180,649,624 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	49,543,566 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; apex of heart; ; right lung; ; upper lobe of left lung; ; sural nerve; ; spleen; ; right uterine tube; ; left uterine tube; ; body of uterus;
	Top expressed in
	endothelial cell of lymphatic vessel; ; internal carotid artery; ; left lobe of liver; ; decidua; ; external carotid artery; ; mesenteric lymph nodes; ; left lung; ; left lung lobe; ; right lung; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	vascular endothelial growth factor-activated receptor activity; transferase activity; nucleotide binding; protein kinase activity; growth factor binding; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; protein phosphatase binding; ATP binding; protein homodimerization activity; receptor tyrosine kinase; transmembrane signaling receptor activity; vascular endothelial growth factor binding;
Cellular component	cytoplasm; integral component of membrane; membrane; receptor complex; plasma membrane; integral component of plasma membrane; extracellular region; nucleus; nucleoplasm;
Biological process	regulation of blood vessel remodeling; positive regulation of protein phosphorylation; positive regulation of endothelial cell proliferation; blood vessel morphogenesis; lymphangiogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein kinase C signaling; negative regulation of apoptotic process; sprouting angiogenesis; positive regulation of JNK cascade; lymph vessel development; positive regulation of endothelial cell migration; protein phosphorylation; vascular endothelial growth factor receptor signaling pathway; vasculature development; angiogenesis; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; protein autophosphorylation; positive regulation of vascular endothelial growth factor production; peptidyl-tyrosine phosphorylation; cellular response to vascular endothelial growth factor stimulus; positive regulation of MAPK cascade; lung alveolus development; respiratory system process; respiratory gaseous exchange by respiratory system; vascular endothelial growth factor signaling pathway; negative regulation of signal transduction; cell differentiation; positive regulation of phosphatidylinositol 3-kinase signaling;
	Sources:Amigo / QuickGO
Orthologs
	2324
	14257
	ENSG00000037280
	ENSMUSG00000020357
	P35916
	P35917
	NM_002020; NM_182925; NM_001354989
	NM_008029
	NP_002011; NP_891555; NP_001341918
	NP_032055
	Wikidata
View/Edit Human	View/Edit Mouse

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.