FNIP1

FNIP1
Identifiers
Aliases	FNIP1, folliculin interacting protein 1, IMD93
External IDs	OMIM: 610594; MGI: 2444668; HomoloGene: 28173; GeneCards: FNIP1; OMA:FNIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	131,797,017 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	54,409,061 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; synovial membrane; ; Skeletal muscle tissue of rectus abdominis; ; corpus callosum; ; pancreatic epithelial cell; ; vastus lateralis muscle; ; pancreatic ductal cell; ; deltoid muscle; ; Achilles tendon;
	Top expressed in
	intercostal muscle; ; soleus muscle; ; myocardium of ventricle; ; iris; ; spermatocyte; ; calvaria; ; stroma of bone marrow; ; gastrocnemius muscle; ; lobe of cerebellum; ; Region I of hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; guanyl-nucleotide exchange factor activity; ATPase inhibitor activity; chaperone binding;
Cellular component	cytoplasm;
Biological process	regulation of protein phosphorylation; regulation of pro-B cell differentiation; cellular response to starvation; negative regulation of TOR signaling; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of protein phosphorylation; negative regulation of transcription by RNA polymerase II; TOR signaling; positive regulation of B cell apoptotic process; positive regulation of protein-containing complex assembly; immature B cell differentiation; positive regulation of peptidyl-serine phosphorylation; mitochondrion organization; TORC1 signaling; negative regulation of mitochondrion organization; negative regulation of TORC1 signaling;
	Sources:Amigo / QuickGO
Orthologs
	96459
	216742
	ENSG00000217128
	ENSMUSG00000035992
	Q8TF40
	Q68FD7
	NM_133372; NM_001008738; NM_001346113; NM_001346114
	NM_173753
	NP_001008738; NP_001333042; NP_001333043; NP_588613
	NP_776114
	Wikidata
View/Edit Human	View/Edit Mouse

Folliculin-interacting protein 1 (FNIP1) functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. FNIP1 acts as a scaffold to load FLCN onto Hsp90. FNIP1 is also involved in chaperoning of both kinase and non-kinase clients.