FNTA

FNTA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JCQ, 1LD7, 1LD8, 1MZC, 1S63, 1SA4, 1TN6, 2F0Y, 2H6F, 2H6G, 2H6H, 2H6I, 2IEJ, 3E37
Identifiers
Aliases	FNTA, FPTA, PGGT1A, PTAR2, farnesyltransferase, CAAX box, alpha
External IDs	OMIM: 134635; MGI: 104683; HomoloGene: 1534; GeneCards: FNTA; OMA:FNTA - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	43,085,788 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,505,678 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; olfactory bulb; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; pancreatic ductal cell; ; amniotic fluid; ; parotid gland; ; skin of hip; ; germinal epithelium; ; trigeminal ganglion;
	Top expressed in
	medullary collecting duct; ; facial motor nucleus; ; fossa; ; Paneth cell; ; condyle; ; vestibular membrane of cochlear duct; ; renal corpuscle; ; substantia nigra; ; ciliary body; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein prenyltransferase activity; protein geranylgeranyltransferase activity; microtubule binding; Rab geranylgeranyltransferase activity; receptor tyrosine kinase binding; alpha-tubulin binding; protein farnesyltransferase activity; acetylcholine receptor regulator activity; protein binding; prenyltransferase activity; CAAX-protein geranylgeranyltransferase activity;
Cellular component	cytoplasm; cytosol; protein farnesyltransferase complex; microtubule associated complex; CAAX-protein geranylgeranyltransferase complex; plasma membrane;
Biological process	positive regulation of tubulin deacetylation; protein prenylation; protein geranylgeranylation; neuromuscular junction development; skeletal muscle acetylcholine-gated channel clustering; positive regulation of deacetylase activity; protein farnesylation; transforming growth factor beta receptor signaling pathway; neurotransmitter receptor metabolic process; regulation of neurotransmitter receptor activity; regulation of rhodopsin mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2339
	14272
	ENSG00000168522
	ENSMUSG00000015994
	P49354
	Q61239
	NM_001018676; NM_001018677; NM_002027
	NM_008033
	NP_002018
	NP_032059
	Wikidata
View/Edit Human	View/Edit Mouse

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene.

Prenyltransferases attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of protein's with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants encoding different isoforms.