FOXA1

FOXA1
Identifiers
Aliases	FOXA1, HNF3A, TCF3A, forkhead box A1
External IDs	OMIM: 602294; MGI: 1347472; HomoloGene: 3307; GeneCards: FOXA1; OMA:FOXA1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	37,596,059 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	57,593,702 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; epithelium of bronchus; ; bronchial epithelial cell; ; right lobe of liver; ; prostate; ; rectum; ; nasal epithelium; ; mucosa of transverse colon; ; mucosa of paranasal sinus; ; body of stomach;
	Top expressed in
	mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; epithelium of stomach; ; mucous cell of stomach; ; lacrimal gland; ; pyloric antrum; ; Paneth cell; ; right lung lobe; ; left colon; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; DNA-binding transcription factor activity; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	microvillus; nucleus; fibrillar center; nucleoplasm;
Biological process	Notch signaling pathway; prostate gland stromal morphogenesis; dopaminergic neuron differentiation; positive regulation of intracellular estrogen receptor signaling pathway; response to estradiol; regulation of transcription, DNA-templated; lung morphogenesis; glucose homeostasis; positive regulation of smoothened signaling pathway; lung development; regulation of transcription by RNA polymerase II; neuron fate specification; anatomical structure formation involved in morphogenesis; positive regulation of mitotic cell cycle; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; tube morphogenesis; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; transcription, DNA-templated; regulation of cell cycle; multicellular organism development; prostate gland epithelium morphogenesis; connective tissue development; positive regulation of neuron differentiation; epithelial cell maturation involved in prostate gland development; regulation of gene expression; lung epithelial cell differentiation; dorsal/ventral neural tube patterning; epithelial-mesenchymal signaling involved in prostate gland development; epithelial tube branching involved in lung morphogenesis; respiratory basal cell differentiation; hormone metabolic process; alveolar secondary septum development; negative regulation of epithelial to mesenchymal transition; positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of transcription by RNA polymerase II; chromatin remodeling; anatomical structure morphogenesis; positive regulation of apoptotic process; chromatin organization; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3169
	15375
	ENSG00000129514
	ENSMUSG00000035451
	P55317
	P35582
	NM_004496
	NM_008259
	NP_004487
	NP_032285
	Wikidata
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Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.