FOXA2

FOXA2
Identifiers
Aliases	FOXA2, HNF3B, TCF3B, forkhead box A2, HNF-3-beta
External IDs	OMIM: 600288; MGI: 1347476; HomoloGene: 7762; GeneCards: FOXA2; OMA:FOXA2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	22,585,455 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	147,888,889 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; pylorus; ; buccal mucosa cell; ; beta cell; ; right uterine tube; ; right lobe of liver; ; cardia; ; body of pancreas; ; lower lobe of lung; ; testicle;
	Top expressed in
	endoderm; ; neural plate; ; epithelium of stomach; ; notochord; ; islet of Langerhans; ; embryonic organizer; ; Hindgut; ; mucous cell of stomach; ; pyloric antrum; ; floor plate;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein domain specific binding; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; cell junction; nucleus;
Biological process	dopaminergic neuron differentiation; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of transcription, DNA-templated; positive regulation of gastrulation; response to interleukin-6; positive regulation of transcription from RNA polymerase II promoter by glucose; regulation of transcription by RNA polymerase II; cell fate specification; adult locomotory behavior; negative regulation of DNA-binding transcription factor activity; transcription, DNA-templated; positive regulation of transcription, DNA-templated; multicellular organism development; negative regulation of glucokinase activity; negative regulation of detection of glucose; regulation of blood coagulation; positive regulation of embryonic development; primitive streak formation; negative regulation of epithelial to mesenchymal transition; endocrine pancreas development; positive regulation of transcription by RNA polymerase II; positive regulation of cell-cell adhesion mediated by cadherin; anatomical structure morphogenesis; chromatin organization; negative regulation of transcription from RNA polymerase II promoter by glucose; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3170
	15376
	ENSG00000125798
	ENSMUSG00000037025
	Q9Y261
	P35583
	NM_021784; NM_153675
	NM_001291065; NM_001291067; NM_010446
	NP_068556; NP_710141
	NP_001277994; NP_001277996; NP_034576
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.