Forkhead box C1

FOXC1
Identifiers
Aliases	FOXC1, ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3, forkhead box C1, ASGD3
External IDs	OMIM: 601090; MGI: 1347466; HomoloGene: 20373; GeneCards: FOXC1; OMA:FOXC1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	1,613,897 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	31,996,459 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; vena cava; ; trigeminal ganglion; ; renal medulla; ; palpebral conjunctiva; ; tibia; ; endothelial cell; ; cartilage tissue; ; nipple; ; urethra;
	Top expressed in
	parotid gland; ; lacrimal gland; ; stria vascularis; ; interatrial septum; ; calvaria; ; ascending aorta; ; paraxial mesoderm; ; conjunctival fornix; ; pulmonary valve; ; septum primum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA binding, bending; transcription coactivator binding; transcription coactivator activity; transcription factor binding; promoter-specific chromatin binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus; cytosol;
Biological process	eye development; somitogenesis; Notch signaling pathway; skeletal system development; glycosaminoglycan metabolic process; positive regulation of hematopoietic progenitor cell differentiation; regulation of transcription, DNA-templated; neural crest cell development; paraxial mesoderm formation; ossification; vascular endothelial growth factor signaling pathway; collagen fibril organization; maintenance of lens transparency; heart morphogenesis; in utero embryonic development; cardiac muscle cell proliferation; lymph vessel development; transcription, DNA-templated; embryonic heart tube development; positive regulation of hematopoietic stem cell differentiation; odontogenesis of dentin-containing tooth; positive regulation of transcription, DNA-templated; ventricular cardiac muscle tissue morphogenesis; heart development; blood vessel remodeling; brain development; vascular endothelial growth factor receptor signaling pathway; negative regulation of lymphangiogenesis; blood vessel development; positive regulation of gene expression; mesenchymal cell differentiation; mesenchymal cell development; artery morphogenesis; ovarian follicle development; negative regulation of angiogenesis; camera-type eye development; regulation of organ growth; germ cell migration; lacrimal gland development; negative regulation of mitotic cell cycle; negative regulation of apoptotic process involved in outflow tract morphogenesis; transcription by RNA polymerase II; endochondral ossification; cell population proliferation; positive regulation of epithelial to mesenchymal transition; cell migration; positive regulation of DNA binding; positive regulation of transcription by RNA polymerase II; cellular response to epidermal growth factor stimulus; positive regulation of core promoter binding; negative regulation of transcription by RNA polymerase II; cerebellum development; positive regulation of keratinocyte differentiation; glomerular epithelium development; ureteric bud development; kidney development; chemokine-mediated signaling pathway; cellular response to chemokine; angiogenesis; multicellular organism development; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2296
	17300
	ENSG00000054598
	ENSMUSG00000050295
	Q12948
	Q61572
	NM_001453
	NM_008592
	NP_001444
	NP_032618
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene.