Forkhead box d1

FOXD1
Identifiers
Aliases	FOXD1, FKHL8, FREAC-4, FREAC4, forkhead box D1
External IDs	OMIM: 601091; MGI: 1347463; HomoloGene: 3290; GeneCards: FOXD1; OMA:FOXD1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	73,448,777 bp
RNA expression pattern
	Top expressed in
	tibia; ; sural nerve; ; trigeminal ganglion; ; cartilage tissue; ; spinal ganglia; ; retinal pigment epithelium; ; gonad; ; stromal cell of endometrium; ; testicle; ; metanephros;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; DNA binding, bending; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; branching involved in ureteric bud morphogenesis; kidney development; transcription by RNA polymerase II; axon guidance; positive regulation of gene expression; positive regulation of BMP signaling pathway; luteinizing hormone secretion; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; dichotomous subdivision of terminal units involved in ureteric bud branching; nephrogenic mesenchyme development; metanephric nephron development; metanephric capsule development; metanephric capsule specification; pattern specification involved in metanephros development; positive regulation of kidney development; anatomical structure morphogenesis; cell differentiation; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	2297
	15229
	ENSG00000251493
	n/a
	Q16676
	Q61345
	NM_004472
	NM_008242
	NP_004463
	NP_032268
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene. Forkhead d1 is a kidney expressed transcription factor maps at the chromosome 5 at position 5q12—q13, identified in Drosophila forkhead protein and mammalian HNF3 transcription factor. The name of the protein was derived from two spiked head structures in the embryos of Drosophila forkhead mutant. It belongs to the transcription factor family, that displays remarkable functional diversity and is involved in a wide variety of biological processes. The most commonly used synonyms for Forkhead D1 are, FOX D1, FREAC-4 and BF2.