FOXN3

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628; MGI: 1918625; HomoloGene: 3809; GeneCards: FOXN3; OMA:FOXN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	89,619,149 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	99,529,841 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; tendon of biceps brachii; ; nipple; ; saphenous vein; ; skin of hip; ; skin of arm; ; mucosa of paranasal sinus; ; skin of thigh; ; synovial joint; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	zygote; ; secondary oocyte; ; hand; ; ascending aorta; ; soleus muscle; ; Rostral migratory stream; ; tibialis anterior muscle; ; foot; ; gastrocnemius muscle; ; aortic valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein C-terminus binding; protein binding; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	cell cycle; mitotic G2 DNA damage checkpoint signaling; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; craniofacial suture morphogenesis; cell differentiation; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1112
	71375
	ENSG00000053254
	ENSMUSG00000033713
	O00409
	Q499D0
	NM_005197; NM_001085471
	NM_183186
	NP_001078940; NP_005188
	NP_899009
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.