FOXRED1

FOXRED1
Identifiers
Aliases	FOXRED1, H17, FP634, FAD-dependent oxidoreductase domain containing 1, FAD dependent oxidoreductase domain containing 1, MC1DN19
External IDs	OMIM: 613622; MGI: 2446262; HomoloGene: 9712; GeneCards: FOXRED1; OMA:FOXRED1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,278,131 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,122,351 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; right lobe of liver; ; cingulate gyrus; ; anterior cingulate cortex; ; apex of heart; ; prefrontal cortex; ; C1 segment; ; Hypothalamus;
	Top expressed in
	spermatocyte; ; brown adipose tissue; ; right kidney; ; proximal tubule; ; interventricular septum; ; ectoderm; ; myocardium of ventricle; ; otic vesicle; ; otic placode; ; saccule;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity;
Cellular component	respirasome; membrane; integral component of membrane; mitochondrial inner membrane; mitochondrion; mitochondrial respiratory chain complex I; cytoplasm;
Biological process	mitochondrial respiratory chain complex I assembly;
	Sources:Amigo / QuickGO
Orthologs
	55572
	235169
	ENSG00000110074
	ENSMUSG00000039048
	Q96CU9
	Q3TQB2
	NM_017547
	NM_001291448; NM_001291449; NM_172291; NM_001359815
	NP_060017
	NP_001278377; NP_001278378; NP_758495; NP_001346744
	Wikidata
View/Edit Human	View/Edit Mouse

FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1), also known as H17, or FP634 is an enzyme that in humans is encoded by the FOXRED1 gene. FOXRED1 is an oxidoreductase and complex I-specific molecular chaperone involved in the assembly and stabilization of NADH dehydrogenase (ubiquinone) also known as complex I, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in FOXRED1 have been associated with Leigh syndrome and infantile-onset mitochondrial encephalopathy.