Folylpolyglutamate synthase

FPGS
Identifiers
Aliases	FPGS, folylpolyglutamate synthase
External IDs	OMIM: 136510; MGI: 95576; HomoloGene: 6997; GeneCards: FPGS; OMA:FPGS - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,814,327 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,594,157 bp
RNA expression pattern
	Top expressed in
	left ovary; ; right ovary; ; left uterine tube; ; gastric mucosa; ; left adrenal cortex; ; right uterine tube; ; right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; canal of the cervix;
	Top expressed in
	left lobe of liver; ; zygote; ; secondary oocyte; ; right kidney; ; proximal tubule; ; primary oocyte; ; spermatid; ; tail of embryo; ; yolk sac; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ligase activity; ATP binding; tetrahydrofolylpolyglutamate synthase activity; metal ion binding; dihydrofolate synthase activity;
Cellular component	cytosol; membrane; mitochondrial inner membrane; cytoplasm; mitochondrion; mitochondrial matrix;
Biological process	one-carbon metabolic process; biosynthesis; brain development; folic acid metabolic process; animal organ regeneration; liver development; glutamate metabolic process; cell population proliferation; nucleobase-containing compound metabolic process; folic acid-containing compound biosynthetic process; folic acid-containing compound metabolic process; tetrahydrofolylpolyglutamate biosynthetic process; dihydrofolate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2356
	14287
	ENSG00000136877
	ENSMUSG00000009566
	Q05932
	P48760
	NM_001018078; NM_001288803; NM_004957
	NM_010236
	NP_001018088; NP_001275732; NP_004948
	NP_034366
	Wikidata
View/Edit Human	View/Edit Mouse

Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.