Formyl peptide receptor 1

FPR1
Identifiers
Aliases	FPR1, FMLP, FPR, formyl peptide receptor 1
External IDs	OMIM: 136537; MGI: 107443; HomoloGene: 20466; GeneCards: FPR1; OMA:FPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,804,110 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	18,104,202 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; periodontal fiber; ; granulocyte; ; trabecular bone; ; spleen; ; bone marrow; ; right lung; ; upper lobe of left lung; ; bone marrow cells;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; right lung lobe; ; stroma of bone marrow; ; blood; ; embryo; ; spleen; ; left lung; ; left lung lobe; ; liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RAGE receptor binding; signal transducer activity; G protein-coupled receptor activity; protein binding; N-formyl peptide receptor activity; complement receptor activity; G protein-coupled receptor binding; scavenger receptor binding;
Cellular component	plasma membrane; membrane; integral component of membrane; integral component of plasma membrane; secretory granule membrane; azurophil granule membrane; ficolin-1-rich granule membrane; intracellular anatomical structure; cytoplasm;
Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; nitric oxide mediated signal transduction; G protein-coupled receptor signaling pathway; signal transduction; chemotaxis; complement receptor mediated signaling pathway; inflammatory response; positive regulation of cytosolic calcium ion concentration; neutrophil degranulation; leukocyte migration; cell chemotaxis; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2357
	14293
	ENSG00000171051
	ENSMUSG00000045551
	P21462
	P33766
	NM_002029; NM_001193306
	NM_013521
	NP_001180235; NP_002020
	NP_038549
	Wikidata
View/Edit Human	View/Edit Mouse

Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell surface receptor protein that in humans is encoded by the formyl peptide receptor 1 (FPR1) gene. This gene encodes a G protein-coupled receptor cell surface protein that binds and is activated by N-Formylmethionine-containing oligopeptides, particularly N-Formylmethionine-leucyl-phenylalanine (FMLP). FPR1 is prominently expressed by mammalian phagocytic and blood leukocyte cells where it functions to mediate these cells' responses to the N-formylmethionine-containing oligopeptides which are released by invading microorganisms and injured tissues. FPR1 directs these cells to sites of invading pathogens or disrupted tissues and then stimulates these cells to kill the pathogens or to remove tissue debris; as such, it is an important component of the innate immune system that operates in host defense and damage control.

Humans also express two paralogs of FPR1 vis., FPR2 and FPR3. Mice express no fewer than 7 Fpr receptors and encoding genes that are homologous to FPR1 although no single one of these FPRs appears to perform exactly the same functions as any one of the human FPRs.