Formyl peptide receptor 2

FPR2
Identifiers
Aliases	FPR2, ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R, formyl peptide receptor 2, ALX
External IDs	OMIM: 136538; MGI: 1278319; HomoloGene: 74395; GeneCards: FPR2; OMA:FPR2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,770,531 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	18,114,214 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; bone marrow; ; bone marrow cells; ; right lung; ; spleen; ; appendix; ; periodontal fiber; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; right lung lobe; ; blood; ; bone marrow; ; stroma of bone marrow; ; left lung lobe; ; spleen; ; substantia nigra; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; complement receptor activity; N-formyl peptide receptor activity; amyloid-beta binding; scavenger receptor binding; cargo receptor activity; signaling receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; integral component of plasma membrane; specific granule membrane; tertiary granule membrane; ficolin-1-rich granule membrane; cytoplasm;
Biological process	inflammatory response; signal transduction; cell adhesion; chemotaxis; G protein-coupled receptor signaling pathway; complement receptor mediated signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; neutrophil degranulation; leukocyte migration; cell chemotaxis; microglial cell activation; positive regulation of protein phosphorylation; receptor-mediated endocytosis; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; calcium-mediated signaling; positive regulation of superoxide anion generation; astrocyte activation; positive chemotaxis; positive regulation of 1-phosphatidylinositol-3-kinase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of monocyte chemotaxis; cellular response to amyloid-beta; immune response-regulating cell surface receptor signaling pathway; cell surface receptor signaling pathway; defense response to bacterium; positive regulation of innate immune response; negative regulation of inflammatory response; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	2358
	14289
	ENSG00000171049
	ENSMUSG00000052270
	P25090
	O88536
	NM_001005738; NM_001462
	NM_008039
	NP_001005738; NP_001453
	NP_032065
	Wikidata
View/Edit Human	View/Edit Mouse

N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4) and long chain Ceramide . Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor.