FRAT1

FRAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GNG, 3ZRK, 3ZRL, 3ZRM, 4AFJ
Identifiers
Aliases	FRAT1, WNT signaling pathway regulator, FRAT regulator of WNT signaling pathway 1
External IDs	OMIM: 602503; MGI: 109450; HomoloGene: 3999; GeneCards: FRAT1; OMA:FRAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,321,915 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,821,022 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; testicle; ; granulocyte; ; pancreatic ductal cell; ; secondary oocyte; ; gonad; ; right lobe of liver; ; bone marrow; ; spleen;
	Top expressed in
	spermatid; ; granulocyte; ; muscle of thigh; ; neural layer of retina; ; embryo; ; spermatocyte; ; morula; ; duodenum; ; CA3 field; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; intracellular membrane-bounded organelle; cytoplasm;
Biological process	Wnt signaling pathway; beta-catenin destruction complex disassembly; canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10023
	14296
	ENSG00000165879
	ENSMUSG00000067199
	Q92837
	P70339
	NM_181355; NM_005479
	NM_008043
	NP_005470
	NP_032069
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.

The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.