FRAT2

FRAT2
Identifiers
Aliases	FRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDs	OMIM: 605006; MGI: 2673967; HomoloGene: 8095; GeneCards: FRAT2; OMA:FRAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,334,729 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,836,571 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; secondary oocyte; ; mucosa of transverse colon; ; bone marrow; ; trabecular bone; ; jejunal mucosa; ; duodenum; ; palpebral conjunctiva;
	Top expressed in
	spermatid; ; left colon; ; granulocyte; ; ventricular zone; ; extensor digitorum longus muscle; ; fetal liver hematopoietic progenitor cell; ; vastus lateralis muscle; ; ganglionic eminence; ; knee joint; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	cytosol; cellular component; cytoplasm;
Biological process	multicellular organism development; cell population proliferation; Wnt signaling pathway; beta-catenin destruction complex disassembly;
	Sources:Amigo / QuickGO
Orthologs
	23401
	212398
	ENSG00000181274
	ENSMUSG00000047604
	O75474
	Q8K025
	NM_012083
	NM_177603
	NP_036215
	NP_808271
	Wikidata
View/Edit Human	View/Edit Mouse

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.