FRS2

FRS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XR0, 2MFQ
Identifiers
Aliases	FRS2, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A, fibroblast growth factor receptor substrate 2
External IDs	OMIM: 607743; MGI: 1100860; HomoloGene: 4846; GeneCards: FRS2; OMA:FRS2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	69,579,793 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; endothelial cell; ; ventricular zone; ; testicle; ; epithelium of colon; ; gonad; ; ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; C1 segment;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity; fibroblast growth factor receptor binding; neurotrophin TRKA receptor binding; protein binding; phosphatase activator activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	cytoplasm; endosome; membrane; plasma membrane; integral component of plasma membrane; endomembrane system; cell-cell junction; cytosol;
Biological process	regulation of apoptotic process; G protein-coupled receptor signaling pathway; ventricular septum development; organ induction; transmembrane receptor protein tyrosine kinase signaling pathway; gastrulation with mouth forming second; MAPK cascade; lens placode formation involved in camera-type eye formation; fibroblast growth factor receptor signaling pathway; transmembrane receptor protein tyrosine phosphatase signaling pathway; lens development in camera-type eye; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; regulation of ERK1 and ERK2 cascade; neuroblast proliferation; forebrain development; regulation of epithelial cell proliferation; anterior/posterior axis specification, embryo; lens fiber cell development; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; axon guidance; negative regulation of cardiac muscle cell differentiation; positive regulation of protein kinase B signaling; neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10818
	327826
	ENSG00000166225
	ENSMUSG00000020170
	Q8WU20
	Q8C180
NM_006654; NM_001042555; NM_001278351; NM_001278353; NM_001278354;
	NM_001278355; NM_001278356; NM_001278357
	NM_177798
NP_001036020; NP_001265280; NP_001265282; NP_001265283; NP_001265284;
	NP_001265285; NP_001265286; NP_006645
NP_808466; NP_001395211; NP_001395212; NP_001395213; NP_001395214;
	NP_001395215; NP_001395216; NP_001395217; NP_001395218; NP_001395219; NP_001395220; NP_001395221; NP_001395222; NP_001395223; NP_001395224; NP_001395225; NP_001395226; NP_001395237; NP_001395238; NP_001395239; NP_001395240; NP_001395241; NP_001395242; NP_001395243
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. It is overexpressed and amplified in several cancer types, including prostate cancer.