FTO gene

FTO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LFM, 4IDZ, 4IE0, 4IE4, 4IE5, 4IE6, 4IE7, 4CXW, 4CXX, 4CXY, 4QHO, 4QKN, 4ZS3, 4ZS2
Identifiers
Aliases	FTO, ALKBH9, GDFD, BMIQ14, fat mass and obesity associated, alpha-ketoglutarate dependent dioxygenase
External IDs	OMIM: 610966; MGI: 1347093; HomoloGene: 8053; GeneCards: FTO; OMA:FTO - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	54,158,512 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	92,395,067 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; Brodmann area 10; ; middle frontal gyrus; ; frontal pole; ; pars compacta; ; corpus callosum; ; dorsal motor nucleus of vagus nerve; ; lactiferous duct; ; inferior olivary nucleus; ; Brodmann area 46;
	Top expressed in
	genital tubercle; ; ventral tegmental area; ; superior colliculus; ; dorsal tegmental nucleus; ; dorsomedial hypothalamic nucleus; ; habenula; ; pontine nuclei; ; tail of embryo; ; subiculum; ; inferior colliculi;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidative DNA demethylase activity; dioxygenase activity; metal ion binding; DNA-N1-methyladenine dioxygenase activity; oxidoreductase activity; ferrous iron binding; mRNA N6-methyladenosine dioxygenase activity; oxidative RNA demethylase activity;
Cellular component	nuclear speck; nucleus; nucleoplasm;
Biological process	regulation of multicellular organism growth; regulation of respiratory system process; regulation of white fat cell proliferation; cellular response to DNA damage stimulus; oxidative demethylation; oxidative single-stranded RNA demethylation; regulation of lipid storage; RNA repair; adipose tissue development; DNA demethylation; regulation of brown fat cell differentiation; temperature homeostasis; oxidative single-stranded DNA demethylation; DNA repair; DNA dealkylation involved in DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	79068
	26383
	ENSG00000140718
	ENSMUSG00000055932
	Q9C0B1
	Q8BGW1
	NM_001080432
	NM_011936
NP_001073901; NP_001350820; NP_001350823; NP_001350825; NP_001350826;
	NP_001350827; NP_001350828; NP_001350829; NP_001350830; NP_001350832; NP_001350834; NP_001350917
	NP_036066
	Wikidata
View/Edit Human	View/Edit Mouse

Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. Certain alleles of the FTO gene appear to be correlated with obesity in humans.